The Small Fiber Neuropathy Network
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📚 Evidence-Based Information: All medical content on this website is backed by peer-reviewed journals, systematic reviews, clinical trials, and reputable medical organizations. We carefully summarize, paraphrase, and reference only credible scientific literature from leading medical institutions. View our comprehensive sources page with 70+ citations from top-tier medical journals. Spotted any discrepancies or questionable sources? We'd love to hear from you.

Clinical Trials

Information about current and upcoming clinical trials for Small Fiber Neuropathy treatments and research opportunities for patients.

Participating in clinical trials can provide access to cutting-edge treatments while contributing to advancing SFN research for the entire community.

Active Clinical Trials

IVIG Treatment for Autoimmune Small Fiber Neuropathy

Currently Recruiting

Study ID: NCT04153422

Location: Evanston, Illinois (Endeavor Health)

Principal Investigator: Dr. Lawrence Zeidman, MD, FAAN

Estimated Completion: February 2028

Study Purpose

This Phase II clinical trial is investigating whether Intravenous Immunoglobulin (IVIG) therapy can improve nerve fiber density and reduce pain in patients with autoimmune small fiber neuropathy. The study specifically focuses on patients with antibodies to TS-HDS, FGFR-3, or Plexin D1.

Key Study Details

  • Study Type: Randomized, double-blind, placebo-controlled Phase II trial
  • Participants: 20 patients (10 treatment, 10 placebo)
  • Treatment: Panzyga IVIG (2g/kg every 4 weeks for 24 weeks) vs. placebo
  • Primary Outcome: Improvement in nerve fiber density on skin biopsy after 6 months
  • Secondary Outcomes: Pain reduction, disability improvement, symptom severity

Who Can Participate?

Inclusion Criteria
  • Age 18 or older
  • Clinical and biopsy evidence of pure small fiber neuropathy
  • Elevated antibodies to TS-HDS-IgM, FGFR3-IgG, or Plexin-D1
  • Baseline pain score ≥ 4/10 on visual scale
  • Utah Early Neuropathy Scale score ≥ 4/10
  • Small Fiber Neuropathy Screening List score ≥ 11/84
Key Exclusion Criteria
  • Other known causes of small fiber neuropathy
  • Evidence of large fiber polyneuropathy on EMG/NCS
  • Severe heart, kidney, liver disease, or HIV infection
  • History of blood clots or hypersensitivity to immunoglobulin
  • Recent use of IgG products (within 6 months)

Why This Study Matters

Small fiber neuropathy affects an increasing number of patients, with 19%-34% of cases having an autoimmune cause. Current treatments like long-term steroids have significant side effects. This study could establish IVIG as an effective, safer treatment option for autoimmune SFN patients.

Study Contact Information

Study Coordinator: Anna Pham

Phone: (847) 503-4344

Email: APham@northshore.org

Principal Investigator: Dr. Lawrence Zeidman

Source: ClinicalTrials.gov - NCT04153422

Additional Small Fiber Neuropathy Clinical Trial

Check Status

Study ID: NCT06287736

Status: Please check ClinicalTrials.gov for current status

Details: Visit the link below for complete study information

Study Information

This is another clinical trial studying Small Fiber Neuropathy. For complete details including eligibility criteria, study purpose, locations, and contact information, please visit the official ClinicalTrials.gov page using the link below.

For Complete Study Details

Visit the official study page on ClinicalTrials.gov for the most up-to-date information about this trial, including eligibility criteria, study locations, and contact information.

Source: ClinicalTrials.gov - NCT06287736

Additional Small Fiber Neuropathy Research Study

Check Status

Study ID: NCT06980948

Status: Please check ClinicalTrials.gov for current status

Details: Visit the link below for complete study information

Study Information

This is another clinical trial studying Small Fiber Neuropathy. For complete details including eligibility criteria, study purpose, locations, and contact information, please visit the official ClinicalTrials.gov page using the link below.

For Complete Study Details

Visit the official study page on ClinicalTrials.gov for the most up-to-date information about this trial, including eligibility criteria, study locations, and contact information.

Source: ClinicalTrials.gov - NCT06980948

🔍 Find More Clinical Trials

Important: All trials listed above are posted on ClinicalTrials.gov, the official U.S. government database of clinical studies.

Search for Trials Near You

We encourage you to search for clinical trials in your area using the official database. New studies are regularly added, and eligibility criteria vary by location and study design.

Search Tips:

  • Use search terms like "Small Fiber Neuropathy" or "Peripheral Neuropathy"
  • Filter by location to find studies near you
  • Check for studies that are "Recruiting" participants
  • Look at both treatment and observational studies
  • Save searches to get notified of new trials
🔍 Search ClinicalTrials.gov for SFN Studies

How to Find and Join Clinical Trials

🔍 Finding Trials

  • Search ClinicalTrials.gov for "small fiber neuropathy"
  • Ask your neurologist or pain specialist about available studies
  • Contact major academic medical centers near you
  • Join our Discord community to hear about new opportunities

📋 Before You Apply

  • Review eligibility criteria carefully
  • Gather your medical records and test results
  • Discuss with your healthcare team
  • Understand the time commitment required
  • Consider travel requirements

❓ Questions to Ask

  • What are the potential benefits and risks?
  • How long will the study last?
  • What tests and procedures are involved?
  • Will my current medications need to change?
  • Are travel expenses covered?

Additional Resources

Clinical Trial Databases

Patient Advocacy

Understanding Clinical Trials